Endocrine Abstracts

The Women’s Health Initiative studies reported that the menopausal hormone therapy (MHT) regimen containing conjugated equine estrogen (CEE) and medroxyprogesterone acetate increased, whereas CEE alone reduced breast cancer incidence. These observations suggest the possibility that CEE might exert unique actions on breast and also suggest the need to eliminate the progestogen from MHT regimens. A MHT regimen called a tissue selective estrogen complex (TSEC), containing CE...

Autopsy studies report a reservoir of small, occult, and undiagnosed breast cancers in up to 15.6% of 40–80-year-old women dying from unrelated causes. Modeling of the biologic behavior of these occult tumors facilitates interpretation of the effects of hormone therapy in menopausal women. We used iterative and mathematical techniques to develop a model of occult tumor growth (OTG) whose parameters included prevalence, effective doubling time (EDT), and detection threshol...